Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1
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چکیده
منابع مشابه
Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.
The Ras effector NORE1 is frequently silenced in primary adenocarcinomas, although the significance of this silencing for tumorigenesis is unclear. Here we show that NORE1 induces polyubiquitination and proteasomal degradation of oncoprotein HIPK1 by facilitating its interaction with the Mdm2 E3 ubiquitin ligase. Endogenous HIPK1 is stabilized in Nore1-deficient mouse embryonic fibroblasts, and...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2011
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2011.235